Preimplantation Genetic Testing
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Center for Reproductive Health
Preimplantation Genetic Testing (PGT)
Preimplantation Genetic Testing (PGT) is an advanced fertility procedure that helps increase the chances of a successful pregnancy by screening embryos for genetic abnormalities before implantation. At the Center for Reproductive Health in Spokane, we offer PGT in combination with IVF to help ensure that only healthy embryos are selected for transfer, reducing the risk of miscarriage or genetic disorders.
Types of Preimplantation Genetic Testing
There are three main types of PGT, each targeting specific genetic issues:
- PGT-A (Preimplantation Genetic Testing for Aneuploidies)
PGT-A screens embryos for chromosomal abnormalities, such as missing or extra chromosomes, which can cause conditions like Down syndrome. This is particularly beneficial for women over 35, those with a history of miscarriages, or couples who have experienced failed IVF cycles - PGT-M (Preimplantation Genetic Testing for Monogenic/Single Gene Defects)
This test is used to detect specific genetic disorders caused by single gene mutations, such as cystic fibrosis or BRCA mutations. It is recommended for couples who are known carriers of genetic diseases or have a family history of such disorders - PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)
PGT-SR identifies structural chromosomal abnormalities, such as translocations or inversions, which often lead to recurrent miscarriages. It is helpful for couples who have experienced multiple pregnancy losses due to chromosomal issues
Benefits of PGT
PGT offers several key benefits, including:
- Reduced Risk of Genetic Disorders: By identifying embryos with genetic defects before implantation, PGT helps reduce the likelihood of passing on hereditary conditions.
- Improved IVF Success Rates: Selecting chromosomally normal embryos increases the chances of a successful implantation and reduces the risk of miscarriage.
- Personalized Family Planning: For couples with genetic concerns, PGT offers peace of mind by enabling the selection of healthy embryos for transfer
What to Expect During PGT
During the IVF process, embryos are biopsied at the blastocyst stage (day 5-7). A small sample of cells is taken and analyzed for genetic abnormalities. The embryos are then cryopreserved while awaiting test results, which typically take about two weeks. Once a healthy, genetically normal embryo is identified, it is transferred to the uterus in a subsequent frozen embryo transfer (FET) cycle
Is PGT Right for You?
PGT is ideal for couples with a history of genetic disorders, recurrent miscarriages, or previous unsuccessful IVF cycles. If you are considering IVF and want to ensure the healthiest embryo is selected for transfer, PGT may be the right option for you.
At the Center for Reproductive Health in Spokane, we provide expert guidance and personalized care throughout your fertility journey, offering cutting-edge treatments like PGT to help you achieve your family-building goals.
To learn more or schedule a consultation, contact us today. We’re here to support you every step of the way.
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Center for Reproductive Health
Frequently Asked Questions About Preimplantation Genetic Testing (PGT)
- PGT-A tests for aneuploidies (abnormal numbers of chromosomes), which can lead to conditions like Down syndrome or miscarriage.
- PGT-M detects specific single-gene mutations, such as those that cause cystic fibrosis or BRCA-related cancers.
- PGT-SR identifies structural chromosomal rearrangements, like translocations, which often result in recurrent miscarriages
PGT is recommended for:
- Couples with a history of genetic disorders or known carriers of genetic mutations.
- Women over 35 or those who have experienced recurrent miscarriages.
- Couples who have had previous failed IVF cycles
While PGT significantly reduces the risk of genetic disorders by selecting embryos with normal chromosomes, it cannot guarantee a healthy baby. Other factors such as implantation success and pregnancy complications still play a role
PGT is performed as part of an IVF cycle. A small sample of cells is biopsied from embryos at the blastocyst stage (day 5-7 of development). The embryos are then frozen while awaiting test results. Healthy, genetically normal embryos are selected for transfer in a future cycle
PGT results typically take about 1-2 weeks to return. During this time, the embryos are cryopreserved to maintain their viability for future transfer
Yes, by selecting embryos that are chromosomally normal, PGT can increase the chances of successful implantation, reduce miscarriage rates, and improve overall IVF success rates
PGT is generally considered safe. The biopsy removes only a few cells from the embryo, and modern techniques ensure minimal risk to its development. However, as with any procedure, there is a small risk associated with embryo manipulation
Insurance coverage for PGT varies. Some insurance plans cover it if there is a medical need, such as a known genetic disorder. It is important to consult your insurance provider or a financial counselor at your fertility clinic